Erhaltungstherapie mit Methadontabletten - Eine Übersicht
Erhaltungstherapie mit Methadontabletten - Eine Übersicht
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The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to suit your needs.
Pregnancy – The disposition of oral methadone has been studied rein approximately 30 pregnant patients hinein 2nd and 3rd trimesters. Elimination of methadone welches significantly changed in pregnancy. Total body clearance of methadone welches increased in pregnant patients compared to the same patients postpartum or to non-pregnant opioid-dependent women. The terminal half-life of methadone is decreased during 2nd and 3rd trimesters.
If you take too much methadone hydrochloride tablets or overdose, call 911 or your local emergency number right away.
Zidovudine – Experimental evidence demonstrated that methadone increased the area under the concentration-time curve (AUC) of zidovudine which could result in toxic effects.
Particular vigilance is necessary during treatment initiation, during conversion from one opioid to another, and during dose titration.
Dispose of any unused methadone hydrochloride tablets remaining from a prescription as soon as they are no longer needed. Unused tablets should Beryllium flushed down the toilet.
The administration of opioids may obscure the diagnosis or clinical course of patients with acute abdominal conditions.
Addiction and misuse warning: Methadone comes with a risk of addiction even when it’s used the right way. This can lead to drug misuse. Having an addiction to and misusing this drug can increase your risk of overdose and death.
Increased side effects from other drugs: Taking methadone with certain medications raises your risk of side effects from those drugs. Examples of these drugs Methadontabletten 10 mg online include:
As with all opioids, administration of this product to the mother shortly before delivery may result rein some degree of respiratory depression hinein the newborn, especially if higher doses are used. Methadone is not recommended for obstetric analgesia because its long duration of action increases the probability of respiratory depression in the newborn.
Do not change your dose unless your doctor tells you to change it. Do not take a higher dose of methadone hydrochloride tablets or take it more often than prescribed. This can lead to an overdose and possibly death.
Anxiety – Since methadone as used by tolerant patients at a constant maintenance dosage does not act as a tranquilizer, patients World health organization are maintained on this drug will react to life problems and stresses with the same symptoms of anxiety as do other individuals.
Methadone has been detected in amniotic fluid and cord plasma at concentrations proportional to maternal plasma and hinein newborn urine at lower concentrations than corresponding maternal urine.
Patients tolerant to other opioids may be incompletely tolerant to methadone. Incomplete cross-tolerance is of particular concern for patients tolerant to other mu-opioid agonists World health organization are being converted to treatment with methadone, thus making determination of dosing during opioid treatment conversion complex. Deaths have been reported during conversion from chronic, high-dose treatment with other opioid agonists. Therefore, it is critical to understand the pharmacokinetics of methadone when converting patients from other opioids (Teich DOSAGE AND ADMINISTRATION, Table 1, for appropriate conversion schedules).